%0 Journal Article
%T ¦¤Np63 regulates the expression of hyaluronic acid-related genes in breast cancer cells
%J -
%D 2018
%R https://doi.org/10.1038/s41389-018-0073-3
%X Triple negative breast cancers (TNBC) represent the most aggressive and clinically relevant breast carcinomas. On the basis of specific molecular signature, the majority of TNBC can be classified as basal-like breast carcinoma. Here, we report data showing that in basal-like breast carcinoma cells ¦¤Np63 is capable of sustaining the production of the hyaluronic acid (HA), one of the major component of the extracellular matrix (ECM). At molecular level, we found that ¦¤Np63 regulates the expression of HA-related genes, such as the HA synthase HAS3, the hyaluronidase HYAL-1 and CD44, the major HA cell membrane receptor. By controlling this pathway, £¿Np63 contributes to maintain the self-renewal of breast cancer stem cells. Importantly, high HAS3 expression is a negative prognostic factor of TNBC patients. Our data suggest that in basal-type breast carcinoma £¿Np63 might favor a HA-rich microenviroment, which can sustain tumor proliferation and stemness
%U https://www.nature.com/articles/s41389-018-0073-3