%0 Journal Article
%T The anticancer potential of metformin on prostate cancer
%J -
%D 2019
%R https://doi.org/10.1038/s41391-018-0085-2
%X Prostate cancer (PCa) is characterized as the most frequent type of cancer in males. Recent research has suggested patients who have diabetes mellitus taking metformin (MF) have a lower risk of PCa. MF has antineoplastic effects such as adenosine monophosphate-activated protein kinase (AMPK)-dependent and independent mechanisms, suppression of androgen signaling pathway, and alterations of insulin-like growth factor-1 (IGF-1) signaling pathways that cause the growth and proliferation of PCa. Based on epidemiological factors, patients with diabetes mellitus may have a protective effect on PCa
%U https://www.nature.com/articles/s41391-018-0085-2