%0 Journal Article
%T Characterization of bone only metastasis patients with respect to tumor subtypes
%J -
%D 2018
%R https://doi.org/10.1038/s41523-018-0054-x
%X Metastatic breast cancer (MBC) patients with bone only metastasis (BOM) are a unique population with limited characterization. We identified patients followed at MD Anderson Cancer Center from 01/01/1997 to 12/31/2015 for at least 6 months with a BOM diagnosis as first site of metastasis. Tumor subtype (TS) was assessed by initial breast biopsy immunohistochemistry using hormonal receptor (HR) and HER2 status, with four subtypes identified: HR+/HER2£¿, HR+/HER2+, HR£¿/HER2£¿, HR£¿/HER2+. HR+ was defined as estrogen receptor or progesterone receptor ¡Ý1%. We identified 1445 patients with BOM, 1048 with TS data available. Among these patients, the majority were HR+/HER2£¿ (78%). Median time from breast cancer diagnosis to first bone metastasis was 2.3 years (95% CI 2.1, 2.5) and varied significantly by TS, with longer time to distant disease in HR+/HER2£¿ patients relative to all other TS (p£¿<£¿.0001). Median overall survival (OS) from breast cancer diagnosis was 8.7 years (95% CI 8.0, 9.7) and varied significantly by TS with poorer OS for HR£¿/HER2£¿ and HR-/HER2+ patients relative to HR+/HER2£¿ TS (p£¿<£¿.0001). The 442 patients with de novo BOM disease, defined as bone metastasis diagnosis within 4 months of breast cancer diagnosis, had significantly shorter OS (p£¿<£¿.0001). Overall, several higher risk BOM subsets were identified in this analysis, most notably HR£¿/HER2+ and HR£¿/HER2£¿ TS and de novo BOM patients
%U https://www.nature.com/articles/s41523-018-0054-x