%0 Journal Article
%T Prognostic and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma
%J -
%D 2019
%R https://doi.org/10.1038/s41375-019-0466-0
%X New prognostic factors are needed to establish indications for haematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) for T-cell lymphoblastic lymphoma (T-LBL) patients. We used microarray to compare T-LBL tissue samples (nˋ=ˋ75) and fetal thymus tissues (nˋ=ˋ20), and identified 35 differentially expressed miRNAs. Using 107 subjects as the training group, we developed a five-miRNA-based classifier to predict patient survival with LASSO Cox regression: lower risk was associated with better prognosis (disease-free survival (DFS): hazard ratio (HR) 4.548, 95% CI 2.433每8.499, pˋ<ˋ0.001; overall survival (OS): HR 5.030, 95% CI 2.407每10.513, pˋ<ˋ0.001). This classifier displayed good performance in the internal testing set (nˋ=ˋ106) and the independent external set (nˋ=ˋ304). High risk was associated with more favorable response to HSCT (DFS: HR 1.675, 95% CI 1.127每2.488, pˋ=ˋ0.011; OS: HR 1.602, 95% CI 1.055每2.433, pˋ=ˋ0.027). When combined with ECOG-PS and/or NOTCH1/FBXW7 status, this classifier had even better prognostic performance in patients receiving HSCT (DFS: HR 2.088, 95% CI 1.290每3.379, pˋ=ˋ0.003; OS: HR 1.996, 95% CI 1.203每3.311, pˋ=ˋ0.007). The five-miRNA classifier may be a useful prognostic biomarker for T-LBL adults, and could identify subjects who could benefit from HSCT
%U https://www.nature.com/articles/s41375-019-0466-0