%0 Journal Article
%T Dirhodium tetracarboxylates as catalysts for selective intermolecular C每H functionalization
%J -
%D 2019
%R https://doi.org/10.1038/s41570-019-0099-x
%X C每H functionalization has become widely recognized as an exciting new strategy for the synthesis of complex molecular targets. Instead of relying on functional groups as the controlling elements of how molecules are assembled, this strategy offers an altogether different logic for organic synthesis. For this type of strategy to be successful, reagents and catalysts need to be developed that generate intermediates that are sufficiently reactive to functionalize C每H bonds but are still capable of distinguishing between the many different C每H bonds and other functional groups present in a molecule. The most well-established approaches have tended to use substrates that inherently have a favoured site for C每H functionalization or rely on intramolecular reactions to control where the reaction will occur. A challenging but potentially more versatile approach would be to use catalysts to control the site selectivity without requiring the influence of any directing group. One example that is capable of achieving such transformations is the C每H insertion chemistry of transient metal carbenes. Dirhodium tetracarboxylates have been shown to be especially effective catalysts for these reactions. This Review highlights the development of these dirhodium catalysts and illustrates their effectiveness to control both site-selective and stereoselective C每H functionalization of a wide variety of substrates
%U https://www.nature.com/articles/s41570-019-0099-x