%0 Journal Article
%T Folate intake and the risk of breast cancer: an up-to-date meta-analysis of prospective studies
%J -
%D 2019
%R https://doi.org/10.1038/s41430-019-0394-0
%X Epidemiological studies focusing on the association between folate and breast cancer risk reported inconsistent findings. We conducted a systematic search of the literature using PubMed and EMBASE databases. A total of 23 prospective studies involving 41,516 cases and 1,171,048 individuals were included for meta-analysis. Folate intake may decrease the risk of oestrogen receptor (ER) negative (ˋ) and ER-/progesterone receptor (PR)- breast cancer, with pooled risk ratios (RRs) of 0.88 [95% confidence interval (CI): 0.78每1.00] and 0.82 (95% CI: 0.68每0.97), respectively. An increment of folate intake of 100ˋ米g per day was associated with a deceased risk of ER- (RRˋ=ˋ0.94, 95% CI: 0.88每0.99) and ER-/PR- (RRˋ=ˋ0.90, 95% CI: 0.85每0.97) breast cancer. Moreover, high folate intake may have preventive effects against breast cancer in premenopausal women (RRˋ=ˋ0.94, 95% CI: 0.88每1.00) and individuals with moderate or high levels of alcohol consumption (RRˋ=ˋ0.82, 95% CI: 0.72每0.94)
%U https://www.nature.com/articles/s41430-019-0394-0