%0 Journal Article
%T MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
%J -
%D 2019
%R https://doi.org/10.1038/s41589-019-0277-7
%X Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibiting NLRP3 activation and inflammasome formation
%U https://www.nature.com/articles/s41589-019-0277-7