%0 Journal Article
%T Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis
%J -
%D 2019
%R https://doi.org/10.1038/s41371-019-0192-0
%X Although emerging evidence suggests that vitamin E may contribute to blood pressure improvement, the effects of vitamin E on systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) are still controversial. The aim was to evaluate the influence of vitamin E on SBP, DBP, and MAP through meta-analysis. We identified all studies that assessed the effect of vitamin E supplementation on SBP, DBP, and MAP from PubMed/Medline, SCOPUS, and Google scholar up to March 2018. Weighted mean differences (WMD) and 95% confidence interval (CI) were expressed as effect size. Pre-specified subgroup analysis was conducted to evaluate potential sources of heterogeneity. Meta-regression analyses were performed to investigate association between blood pressure-lowering effects of vitamin E and duration of follow-up and dose of treatment. Eighteen trials, comprising 839 participants met the eligibility criteria. Results of this study showed that compared to placebo, SBP decreased significantly in vitamin E group (WMD£¿=£¿£¿3.4£¿mmHg, 95% CI£¿=£¿£¿6.7 to £¿0.11, P£¿<£¿0.001), with a high heterogeneity across the studies (I2£¿=£¿94.0%, P£¿<£¿0.001). Overall, there were no significant effects on DBP and MAP. This meta-analysis suggested that vitamin E supplements decreased only SBP and had no favorable effect on DBP and MAP
%U https://www.nature.com/articles/s41371-019-0192-0