%0 Journal Article
%T Activation of silent biosynthetic gene clusters using transcription factor decoys
%J -
%D 2018
%R https://doi.org/10.1038/s41589-018-0187-0
%X Here we report a transcription factor decoy strategy for targeted activation of eight large silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging from 50 to 134 kilobases (kb) in multiple streptomycetes, and characterization of a novel oxazole family compound produced by a 98-kb biosynthetic gene cluster. Owing to its simplicity and ease of use, this strategy can be scaled up readily for discovery of natural products in streptomycetes
%U https://www.nature.com/articles/s41589-018-0187-0