%0 Journal Article
%T DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
%J -
%D 2019
%R https://doi.org/10.1016/j.ccell.2019.02.004
%X £¿ Ovarian cancer cells show differential sensitivity to PARP and PARG inhibitors £¿ PARG inhibitor sensitivity is due to an underlying DNA replication vulnerability £¿ PARG inhibition blocks fork restart leading to persistent replication stress £¿ PARG inhibition sensitizes cells to drugs targeting the CHK1 kinas
%U https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30099-6