%0 Journal Article
%T Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers
%J -
%D 2019
%R https://doi.org/10.1016/j.ccell.2018.12.009
%X £¿ ARID1A maintains GSH homeostasis by enhancing SLC7A11 transcription £¿ Low SLC7A11 expression causes low basal GSH levels in ARID1A-deficient cancer cells £¿ Inhibiting GSH/GCLC in ARID1A-deficient cancer cells causes apoptosis by ROS £¿ GCLC is a druggable synthetic lethal target for ARID1A-deficient cance
%U https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30581-6