%0 Journal Article
%T p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
%J -
%D 2019
%R https://doi.org/10.1016/j.ccell.2019.01.006
%X £¿ Smarcb1-deficient mosaic GEM models recapitulate malignant rhabdoid tumors (MRTs) £¿ Autophagy and UPR are essential adaptive mechanisms to proteotoxic stress in MRTs £¿ The MYC-p53 axis regulates proteostasis in SMARCB1-deficient cells £¿ Autophagy and proteasome inhibitors achieve durable responses in MRT model
%U https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30040-6