%0 Journal Article
%T Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site
%J -
%D 2019
%R https://doi.org/10.1016/j.celrep.2018.12.097
%X £¿ The corepressor SHARP binds the transcription factor RBPJ in a bipartite manner £¿ SHARP binds the BTD and CTD of RBPJ, using motifs analogous to other corepressors £¿ Structure-based mutants affect RBPJ-SHARP complex formation in vitro and in cells £¿ RBPJ mutants are defective in repression from Notch target genes in cell
%U https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32057-6