%0 Journal Article
%T Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation
%J -
%D 2019
%R https://doi.org/10.1016/j.ccell.2019.04.003
%X £¿ TMEM176B inhibits the NLRP3 inflammasome by controlling cytosolic Ca2+. £¿ Lack of Tmem176b enhances antitumor immunity via the caspase-1/IL-1¦Â pathway £¿ Human tumors responding to immune checkpoint blockade display an inflammasome-activated signature £¿ A TMEM176B inhibitor improves the antitumor activity of immune checkpoint blockad
%U https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30198-9