%0 Journal Article
%T Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
%J -
%D 2019
%R https://doi.org/10.1016/j.celrep.2018.12.072
%X £¿ Deletion of MyD88 or TLR4 in IMCs and/or CAFs leads to reduced intestinal tumorigenesis £¿ The phenotype of the IMC-specific MyD88 mice is similar to the complete knockouts £¿ MyD88£¿/£¿ IMCs show a reduced pro-tumorigenic and/or inflammatory gene expression profile £¿ Human CAFs show upregulation of a similar MyD88-specific gene expression signatur
%U https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32017-5