%0 Journal Article
%T Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-¦Â in iPSC-Derived Alzheimer¡¯s Disease Neurons
%J -
%D 2019
%R https://doi.org/10.1016/j.stem.2018.12.013
%X £¿ Drug screening identifies inhibitors of aberrant phosphorylated Tau (pTau) accumulation £¿ Cholesteryl esters (CE) were identified as upstream regulators of pTau proteostasis £¿ The effects of CE on Tau proteostasis are correlated with, but independent of, APP and A¦Â £¿ Lead compound enhance CE-dependent pTau proteasomal turnover specifically in neuron
%U https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30603-9