%0 Journal Article
%T C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2019.03.019
%X £¿ R-rich DPRs sequester NPM1 into large, soluble phase-separation-inhibited complexes £¿ NPM1 sequestration dissolves droplets in vitro and delocalizes nucleolar NPM1 in cells £¿ poly(PR) entraps rRNA in static puncta in vitro and in nucleoli £¿ poly(PR) interactions disrupt nucleolar organization in a length-dependent manne
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30223-0