%0 Journal Article %T In This Issue %J - %D 2019 %R https://doi.org/10.1016/j.chempr.2019.04.018 %X Polariton chemistry is a new class of chemistry that occurs in strongly confined environments, such as optical cavities, where light-matter interactions are modified by the strong coupling limit. In this issue of Chem, Du et al. show a theoretical example where a catalyst is capable of inducing a reaction without touching the reactant when both are confined in a quantum-based optical device. Thanks to the strong coupling of two adjacent optical cavities, the study demonstrates that it would be possible to drive the cis ¡ú trans conformational isomerization of nitrous acid, contained in one cavity, by increasing the photoexcitation of glyoxylic acid in another cavity %U https://www.cell.com/chem/fulltext/S2451-9294(19)30176-7