%0 Journal Article
%T Targeting Mitochondria to Revive Dysfunctional Regulatory T Cells
%J -
%D 2019
%R https://doi.org/10.1016/j.molmed.2018.11.001
%X Immunometabolism is important to T cell dysfunction in chronic infections. A recent publication in The Journal of Clinical Investigation (2018;128:5083¨C5094) [ 1 Younes S.A. et al. Cycling CD4 + T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. J. Clin. Invest. 2018; 128 : 5083-5094 Crossref PubMed Scopus (0) Google Scholar ] shows reduced mitochondrial fitness in regulatory CD4 + T cells (Tregs) of patients with HIV and failed immune restoration on antiretroviral therapy (ART). This defect can be reversed by IL-15, revealing a new immunotherapy target for regulatory T cell restoration
%U https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30209-0