%0 Journal Article
%T Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System
%A Katherine Harding
%A Kristin White
%J -
%D 2018
%R https://doi.org/10.3390/jdb6040025
%X Abstract Stem cells face a diversity of choices throughout their lives. At specific times, they may decide to initiate cell division, terminal differentiation, or apoptosis, or they may enter a quiescent non-proliferative state. Neural stem cells in the Drosophila central nervous system do all of these, at stereotypical times and anatomical positions during development. Distinct populations of neural stem cells offer a unique system to investigate the regulation of a particular stem cell behavior, while comparisons between populations can lead us to a broader understanding of stem cell identity. Drosophila is a well-described and genetically tractable model for studying fundamental stem cell behavior and the mechanisms that underlie cell-fate decisions. This review will focus on recent advances in our understanding of the factors that contribute to distinct stem cell-fate decisions within the context of the Drosophila nervous system. View Full-Tex
%K stem cell biology
%K neuroblast
%K cell cycle
%K apoptosis
%K Drosophila
%K development
%U https://www.mdpi.com/2221-3759/6/4/25