%0 Journal Article
%T Cold Atmospheric Pressure Plasma Treatment Modulates Human Monocytes/Macrophages Responsiveness
%A Alina Bisag
%A Angela Amoruso
%A Anna Liguori
%A Augusto Stancampiano
%A Letizia Crestale
%A Luigia G. Fresu
%A Maria Talmon
%A Matteo Gherardi
%A Romolo Laurita
%A Vittorio Colombo
%J -
%D 2018
%R https://doi.org/10.3390/plasma1020023
%X Abstract Monocytes are involved in innate immune surveillance, establishment and resolution on inflammation, and can polarize versus M1 (pro-inflammatory) or M2 (anti-inflammatory) macrophages. The possibility to control and drive immune cells activity through plasma stimulation is therefore attractive. We focused on the effects induced by cold-atmospheric plasma on human primary monocytes and monocyte-derived macrophages. Monocytes resulted more susceptible than monocyte-derived macrophages to the plasma treatment as demonstrated by the increase in reactive oxygen (ROS) production and reduction of viability. Macrophages instead were not induced to produce ROS and presented a stable viability. Analysis of macrophage markers demonstrated a time-dependent decrease of the M1 population and a correspondent increase of M2 monocyte-derived macrophages (MDM). These findings suggest that plasma treatment may drive macrophage polarization towards an anti-inflammatory phenotype. View Full-Tex
%K cold atmospheric pressure plasma
%K dielectric barrier discharges
%K monocytes
%K monocytes-derived macrophages
%U https://www.mdpi.com/2571-6182/1/2/23