%0 Journal Article
%T IMGT£¿ and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function
%A G¨¦rard Lefranc
%A Marie-Paule Lefranc
%J -
%D 2019
%R https://doi.org/10.3390/antib8020029
%X Abstract At the 10th Human Genome Mapping (HGM10) Workshop, in New Haven, for the first time, immunoglobulin (IG) or antibody and T cell receptor (TR) variable (V), diversity (D), joining (J), and constant (C) genes were officially recognized as ¡®genes¡¯, as were the conventional genes. Under these HGM auspices, IMGT £¿, the international ImMunoGeneTics information system £¿, was created in June 1989 at Montpellier (University of Montpellier and CNRS). The creation of IMGT £¿ marked the birth of immunoinformatics, a new science, at the interface between immunogenetics and bioinformatics. The accuracy and the consistency between genes and alleles, sequences, and three-dimensional (3D) structures are based on the IMGT Scientific chart rules generated from the IMGT-ONTOLOGY axioms and concepts: IMGT standardized keywords (IDENTIFICATION), IMGT gene and allele nomenclature (CLASSIFICATION), IMGT standardized labels (DESCRIPTION), IMGT unique numbering and IMGT Collier de Perles (NUMEROTATION). These concepts provide IMGT £¿ immunoinformatics insights for antibody V and C domain structure and function, used for the standardized description in IMGT £¿ web resources, databases and tools, immune repertoires analysis, single cell and/or high-throughput sequencing (HTS, NGS), antibody humanization, and antibody engineering in relation with effector properties. View Full-Tex
%K IMGT
%K immunoinformatics
%K immunogenetics
%K IMGT-ONTOLOGY
%K IMGT Collier de Perles
%K IMGT unique numbering
%K immunoglobulin
%K antibody
%K paratope
%K complementarity determining region
%U https://www.mdpi.com/2073-4468/8/2/29