%0 Journal Article
%T The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning
%A David J. Reiner
%A Hanna Shin
%J -
%D 2018
%R https://doi.org/10.3390/jdb6040030
%X Abstract EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to assume a precise array of three cell fates with high fidelity. A group of core and modulatory signaling cascades forms a signaling network that demonstrates plasticity during the transition from na£żve to terminally differentiated cells. In this review, we summarize the history of classical developmental manipulations and molecular genetics experiments that led to our understanding of the signals governing this process, and discuss principles of signal transduction and developmental biology that have emerged from these studies. View Full-Tex
%K EGF
%K EGFR
%K Ras
%K Notch
%K DSL
%K Raf
%K RalGEF
%K Ral
%K signal transduction
%K MAP kinase
%U https://www.mdpi.com/2221-3759/6/4/30