%0 Journal Article
%T The Comparison of Corneal Endothelial Cell Properties with the Topographic Ectasia Indexes in Keratoconus
%A Nesrin B¨¹Y¨¹KTORTOP G£¿K£¿INAR
%J -
%D 2019
%X Objective: To investigate the corneal endothelial cell characteristics in eyes with keratoconus and to analyze their correlation with topographic keratoconus screening indices. Material and Methods: In this prospective study, apical curvature and keratoconus screening indexes including thinnest corneal thickness (TCT), symmetry index, keratoconus vertex, and Baiocchi-Calossi-Versaci index were recorded in keratoconus patients and healthy eyes using a combined Scheimpflug-Placido disc corneal topography device (CSO Sirius, Florence, Italy). Corneal endothelium was examined with non-contact specular microscopy device (Konan Cell Check SL, Hyogo, Japan). The endothelial cell density (ECD), coefficient of variation of cell areas (CV) and percentage of hexagonal cells (HEX) were recorded. The keratoconus screening indexes and endothelial cell properties were compared between the keratoconic and healthy eyes. The correlation between topographic indexes and endothelial cell properties was evaluated. Results: In our study, there were 70 eyes of 45 keratoconus patients in the keratoconus group and 50 eyes of 50 healthy volunteers in the control group. Twenty-four eyes were recruited to mild, 36 eyes to medium, and 10 eyes to advanced to keratoconus groups according to the severity of disease. In keratoconus group CV was significantly higher than in the control group (p=0.015). Mean ECD and HEX were also lower than the control group, but this difference was not statistically significant. No significant difference was found between the stages of keratoconus in terms of endothelial cell characteristics (p>0.05). A weak but significant correlation was found between TCT and ECD (r=0.231; p=0.011). There was a weak but significant correlation between CV and most of the keratoconus screening indexes and apical curvature (r=~0.2; p<0.05). Conclusion: Endothelial cell area variation increases in keratoconus. This increase is correlated with topographic keratoconus screening indexes and apical curvature. It should be kept in mind that corneal endothelial cell characteristics may change with the severity of keratoconus
%K Keratokonus
%K kornea topografisi
%K kornea endotel h¨¹cre yo£¿unlu£¿u
%K spek¨¹ler mikroskopi
%U http://dergipark.org.tr/kutfd/issue/47767/555896