%0 Journal Article
%T Amyotrophic Lateral Sclerosis and Gene Mutations
%A Filiz Ko£¿
%J -
%D 2019
%X Amyotrophic lateral sclerosis is a progressive and lethal disease characterized by corticospinal tract, brain stem and spinal cord degeneration of upper and lower motor neurons.1 Ethiology is a multifactorial disease with environmental and genetic causes. 10-20% of the cases are familial and 80-90% are sporadic. He reported that more than 50% of the patients lost their lives within 3 years and 90% lost their lives within 5 years. 2 Genetic mutations have been detected in sporadic and familial cases, more frequently in 2 familial cases. The most common mutation is chromosome 9 open read frame 72. Sporadic dismutase, Transactable response DNA-binding protein 43, Fused in Sarcoma and Ubiquilin 2 are other mutations
%K ALS
%K gen
%K mutasyon
%U http://dergipark.org.tr/aktd/issue/44965/421472