%0 Journal Article
%T Expression and Clinical Significance of <i>PIK3CA</i>, <i>c-MET</i> and <i>c-KIT</i> Mutations in Saudi Breast Cancer Patients
%A Rami Nassir
%A Ghada Esheba
%A Hanan M. Abd Elmoneim
%A Ahlam S. Altowairqi
%A Ghassan Nouman
%J Advances in Breast Cancer Research
%P 60-74
%@ 2168-1597
%D 2021
%I Scientific Research Publishing
%R 10.4236/abcr.2021.103005
%X Objective: PIK3CA is
the most common pathway affected by mutations in breast cancer. PIK3CA/PTEN pathway is under
intense investigation as a possible target for molecular therapy. Dysregulation PIK3CA/PTEN
pathway is a substantial mechanism for the development of resistance to
anti-HER2 therapy. Therefore, we aimed to study the PIK3CA/PTEN in breast cancer
patients in Saudi population. Methods: We applied PTEN
immunohistochemistry on 98 patients. Then, we applied next-generation
sequencing to determine the genetic variations associated with the development
of breast cancer and their correlations with clinicopathological variables. Results: PTEN expression was
significantly correlated with lymph node metastasis (LNM), tumor stage,
lymphovascular invasion (LVI) and triple negative breast cancer (TNBC). The
prevalence of the PIK3CA mutation was 33.3% of cases and it was significantly associated with LNM, tumor
stage, and with PTEN expression. c-MET mutation was
%K PTEN
%K <
%K i>
%K PIK3CA<
%K /i>
%K <
%K i>
%K c-MET<
%K /i>
%K <
%K i>
%K c-KIT<
%K /i>
%K Breast Cancer
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=110353