%0 Journal Article
%T Expression and Clinical Significance of <i>PIK3CA</i>, <i>c-MET</i> and <i>c-KIT</i> Mutations in Saudi Breast Cancer Patients
%A Rami Nassir
%A Ghada Esheba
%A Hanan M. Abd Elmoneim
%A Ahlam S. Altowairqi
%A Ghassan Nouman
%J Advances in Breast Cancer Research
%P 60-74
%@ 2168-1597
%D 2021
%I Scientific Research Publishing
%R 10.4236/abcr.2021.103005
%X <strong>Objective</strong><span style=\"font-family:Verdana;\"><strong>:</strong></span><span style=\"font-family:&quot;\"> <i><span style=\"font-family:Verdana;\">PIK</span></i><span><span style=\"font-family:Verdana;\">3</span><i><span style=\"font-family:Verdana;\">CA</span></i></span><span style=\"font-family:Verdana;\"> is
the most common pathway affected by mutations in breast cancer. </span><i><span style=\"font-family:Verdana;\">PIK</span></i><span><span style=\"font-family:Verdana;\">3</span><i><span style=\"font-family:Verdana;\">CA</span></i></span><span style=\"font-family:Verdana;\">/PTEN pathway is under
intense investigation as a possible target for molecular therapy. Dysregulation </span><i><span style=\"font-family:Verdana;\">PIK</span></i><span><span style=\"font-family:Verdana;\">3</span><i><span style=\"font-family:Verdana;\">CA</span></i></span><span style=\"font-family:Verdana;\">/PTEN
pathway is a substantial mechanism for the development of resistance to
anti-HER2 therapy. Therefore, we aimed to study the </span><i><span style=\"font-family:Verdana;\">PIK</span></i><span><span style=\"font-family:Verdana;\">3</span><i><span style=\"font-family:Verdana;\">CA</span></i></span><span style=\"font-family:Verdana;\">/PTEN in breast cancer
patients in </span><span style=\"font-family:Verdana;\">Saudi</span><span style=\"font-family:Verdana;\"> population. </span><b><span style=\"font-family:Verdana;\">Methods:</span></b><span style=\"font-family:Verdana;\"> We applied PTEN
immunohistochemistry on 98 patients. Then, we applied next-generation
sequencing to determine the genetic variations associated with the development
of breast cancer and their correlations with clinicopathological variables. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">PTEN expression was
significantly correlated with lymph node metastasis (LNM), tumor stage,
lymphovascular invasion (LVI) </span><span style=\"font-family:Verdana;\">and</span> <span style=\"font-family:Verdana;\">triple negative</span><span style=\"font-family:Verdana;\"> breast cancer (TNBC). The
prevalence of the </span><i><span style=\"font-family:Verdana;\">PIK</span></i><span><span style=\"font-family:Verdana;\">3</span><i><span style=\"font-family:Verdana;\">CA</span></i></span><span style=\"font-family:Verdana;\"> mutation was 33.3% of cases and it was significantly associated with LNM, tumor
stage, and with PTEN expression. </span><i><span style=\"font-family:Verdana;\">c-MET</span> </i><span style=\"font-family:Verdana;\">mutation was
%K PTEN
%K &lt
%K i&gt
%K PIK3CA&lt
%K /i&gt
%K &lt
%K i&gt
%K c-MET&lt
%K /i&gt
%K &lt
%K i&gt
%K c-KIT&lt
%K /i&gt
%K Breast Cancer
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=110353