%0 Journal Article
%T Correlation between Alzheimer¡¯s Disease and Dementia with Lewy Bodies Scores Using VSRAD Advance
%A Yukinori Okada
%A Norikazu Ohno
%A Koji Tanaka
%J Advances in Alzheimer's Disease
%P 33-45
%@ 2169-2467
%D 2021
%I Scientific Research Publishing
%R 10.4236/aad.2021.103003
%X The objective of the study was to explore the relationship between the indicators of Alzheimer¡¯s disease and dementia with Lewy bodies using the voxel-based specific regional analysis system for Alzheimer¡¯s Disease (VSRAD) advance. Among 36 patients with suspected dementia, patients with Alzheimer¡¯s disease and dementia with Lewy bodies were identified using VSRAD advance from March 1 to October 30, 2019. All patients underwent brain Magnetic Resonance Imaging (MRI). We diagnosed Alzheimer¡¯s disease using Volume of Interest (VOI) in the Medial Temporal Lobe (MTL) atrophy ratio £¾ 2 and dementia with Lewy bodies using both VOI in the MTL atrophy ratio ¡Ü 2 and gray/white matter atrophy ratio ¡Ý 0.2. The correlation between the indicators of Alzheimer¡¯s disease and dementia with Lewy bodies was calculated. The number of patients classified as having Alzheimer¡¯s disease and dementia with Lewy bodies was 25 and 11, respectively. In the Alzheimer¡¯s disease group, the correlation coefficient between the extent of gray matter atrophy and the severity of atrophy in the dorsal brainstem gray matter was r = -0.40 (p = 0.045). In dementia with Lewy bodies group, the correlation coefficient between the extent of gray matter atrophy and the severity of atrophy in the dorsal brainstem white matter was r = -0.78 (p < 0.01). Using VSRAD advance, gray matter atrophy and dorsal brainstem grey/white matter atrophy were found to be negatively correlated in Alzheimer¡¯s disease and dementia with Lewy bodies.
%K Alzheimer¡¯s Disease
%K Dementia with Lewy Bodies
%K Dorsal Brainstem
%K Gray Matter Atrophy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=110537