%0 Journal Article
%T Predictors for Metachronous Metastases in Early Breast Cancer: A Single Institution Study
%A Haytham Mahmoud Awad Fayed
%A Mohamed Ali Abdalla Billel
%A Galal Mostafa Abouelnagah
%A Gehan A. Khedr
%J Advances in Breast Cancer Research
%P 87-99
%@ 2168-1597
%D 2021
%I Scientific Research Publishing
%R 10.4236/abcr.2021.103007
%X <strong>Background:</strong> <span style=\"font-family:Verdana;\">Breast cancer (BC) is considered the most common women cancer worldwide. </span><span style=\"font-family:Verdana;\">The main clinicopathological prognostic
factors are tumor size, lymph node status and estrogen/progesterone (ER/PR)
receptor status</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:Verdana;\"> In addition, some
factors are both prognostic and predictive as ER/PR receptors and HER2/neu
overexpression. </span><span style=\"font-family:Verdana;\">Axillary lymph node status is the most important
prognostic factor for breast cancer. Node negative breast cancer patients had
the best 5-year overall survival (OS) of 82.8% compared to 73%, 45.7%, and
28.4% for patients with 1</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">3, 4</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">12, and
¡İ13 positive nodes, respectively. </span><span style=\"font-family:Verdana;\">The aim of
this study was</span><span style=\"font-family:Verdana;\"> to determine the association between different
clinicopathological features and </span><span style=\"font-family:Verdana;\">development</span><span style=\"font-family:Verdana;\"> of metastasis in a group of Egyptian women with early breast cancer</span></span><span style=\"font-family:Verdana;\">,</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> also, to assess patients¡¯
Relapse-free survival (DFS) and OS and their correlation with different
clinicopathological features. </span><b><span style=\"font-family:Verdana;\">Patients and Methods: </span></b><span style=\"font-family:Verdana;\">We retrospectively
reviewed the files of breast cancer patients who were treated and </span><span style=\"font-family:Verdana;\">followed-up</span><span style=\"font-family:Verdana;\"> at the clinical oncology department
and surgical oncology unit, Alexandria Main University Hospital during the
period from January 2014 to December 2017. A total of 1848 breast cancer cases
were presented during this </span><span style=\"font-family:Verdana;\">period of time</span><span style=\"font-family:Verdana;\">.
141 out of the 1848 patients developed metastasis from breast cancer during
follow-up. Among the 141 patients, only 102
%K Breast Cancer
%K Metastasis
%K Relapse Free Survival
%K Overall Survival
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=110547