%0 Journal Article
%T Epidemiological, Diagnosis, Therapeutic and Evolving Profile of Triple Negative Breast Cancer in Senegal
%A Papa Macoumba Gaye
%A Mouhamed Diouf
%A Mouhamadou Bachir Ba
%A Doudou Diouf
%A Fatimatou N¨¦n¨¦ Sarr
%A Maimouna Man¨¦
%A Mamadou Sarr
%A Mamadou Moustapha Dieng
%A Sidy Ka
%A Ahmadou Dem
%J Advances in Breast Cancer Research
%P 100-109
%@ 2168-1597
%D 2021
%I Scientific Research Publishing
%R 10.4236/abcr.2021.103008
%X <strong>Objective:</strong><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> Describe the epidemiological, diagnostic, therapeutic and evolutionary
profile of triple negative breast cancer at the Dakar Cancer Institute in
Senegal. </span><b><span style=\"font-family:Verdana;\">Patients and Methods:</span></b><span style=\"font-family:Verdana;\"> This was a retrospective study between
January 1, 2011 and December 31, 2014. All patients with a triple negative
molecular profile were included. The data were collected from the medical
records of the patients. The data were entered and analyzed with SPSS edition
16 software under Windows 7</span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">.</span></span></span><span><span><span style=\"font-family:&quot;\"> <b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">Two hundred and twenty-five patients were selected. The
mean age was 47.9 ¡À 12.5 years with extremes of 25 and 90 years. The main
reason for consultation was dominated by the finding of a breast lump. The mean
clinical tumor size was 8</span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">, </span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">54 cm with a large majority of T3-T4 tumors 26% and 63% respectively,
lymph node involvement in one hundred and seventy-two cases (76.4%); twenty
eight patients (12.4%) were metastatic from the outset. Non-specific invasive
carcinoma was the most common histologic type (78.2%), and more than half of
the patients (53.3%) had an aggressive tumor (Scarff-Bloom-Richardson grading
III). Neoadjuvant chemotherapy was performed in 65.78% of cases. We noted 27.7%
total response and 41.7% partial response in patients who have received this
neoadjuvant chemotherapy. The surgery was radical in 77% of cases, conservative
in 14% and cleanliness surgery for palliative purposes in 9% of cases. Adjuvant
radiotherapy is performed in 58.6% of operated patients. The mean time to
follow-up was 20.63 months with extremes of 1 and 53 months. Overall survival
was 69.8% at one year, 41.6% at two years and 25.6% at three years. </span><b><span style=\"font-family:Verdana;\">Conclusion: </span></b><span style=\"font-family:Verdana;\">The descriptive analysis of these results confirms the high frequency of
triple-negative breast cancer in Senegal
%K Breast Cancer
%K Triple Negative
%K Senegal
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=110764