%0 Journal Article
%T Optimizing Adjuvant Radiation Planning Outcomes in Patients with Synchronous Bilateral Breast Cancer
%A Mohamed M. Alhefny
%A Hany S. Attallah
%A Mahmoud Abdallah
%A Adel Yassin
%A Khaled M. El-Shahat
%A Ahmed A. Obaya
%J Advances in Breast Cancer Research
%P 110-119
%@ 2168-1597
%D 2021
%I Scientific Research Publishing
%R 10.4236/abcr.2021.103009
%X <strong>Background:</strong><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> Breast cancer is the most common cancer diagnosed
worldwide, synchronous bilateral breast cancer accounts for </span><span style=\"font-family:Verdana;\">unique</span><span style=\"font-family:Verdana;\"> entity of the disease, particularly
post-operative radiotherapy for Synchronous Bilateral Breast Cancer (SBBC) is
challenging with </span><span style=\"font-family:Verdana;\">lack</span><span style=\"font-family:Verdana;\"> of evidence about
the best irradiation technique. In this </span><span style=\"font-family:Verdana;\">study</span></span><span style=\"font-family:Verdana;\">,</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> we tried to explore the optimum radiotherapy
technique regarding the dosimetric parameters. </span><b><span style=\"font-family:Verdana;\">Methods:</span></b><span style=\"font-family:Verdana;\"> We recruited 15
SBBC patients in whom </span><span style=\"font-family:Verdana;\">post-operative</span><span style=\"font-family:Verdana;\"> radiotherapy was indicated and we established three plans for each patient
using 3DCRT, IMRT </span><span style=\"font-family:Verdana;\">and</span><span style=\"font-family:Verdana;\"> VMAT, and then we
compared the three plans as regard target volume coverage parameters and organs
at risk (OAR) doses. </span><b><span style=\"font-family:Verdana;\">Results:</span></b><span style=\"font-family:Verdana;\"> We found that PTV coverage parameter was
superior with IMRT compared with 3DCRT and VMAT in terms of Dmean (p = 0.001),
D95% (p = 0.001), D</span><sub><span style=\"font-family:Verdana;\">max</span></sub><span style=\"font-family:Verdana;\"> (p = 0.0001), conformity index (p = 0.0001) and
HI (p = 0.0001). Doses to OAR w</span></span><span style=\"font-family:Verdana;\">ere</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> not significantly different between the three
techniques in </span><span style=\"font-family:Verdana;\">cardiac</span><span style=\"font-family:Verdana;\"> dose and LAD
maximum dose, but 3DCRT was superior in LAD mean dose (p = 0.03) and lung
volume receiving 20 Gy (V20) and 10 Gy (V10) (p = 0.0001), but this difference
was non-significant between 3DCRT and IMRT (p = 0.4 and 0.06 respectively),
while VMAT led to the highest doses to LAD and lung. </span><b><span style=\"font-family:Verdana;\">Conclusions: </span></b><span style=\"font-family:Verdana;\">IMRT
showed the best target coverage parameters in post-operative
%K Synchronous Bilateral Breast Cancer (SBBC)
%K 3DCRT
%K IMRT
%K VMAT
%K Target Volume Coverage
%K OAR
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=110804