%0 Journal Article
%T Chromosome Polymorphism and Human Pathology: About 27 Cases of Chromosome 9 Inversion in the Beninese Population
%A Simon Azonbakin
%A Alfred Ouedraogo
%A Alexis Ouedraogo
%A Daniel Sewadouno
%A Arnaud Agbanlinsou
%A Yannick Goussanou
%A Marius Adjagba
%A Jules Alao
%A Anatole Laleye
%J Open Journal of Genetics
%P 23-31
%@ 2162-4461
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojgen.2021.113003
%X The chromosomal polymorphism defined by variations of some chromosomal regions of a person (the constitutive heterochromatin and the short arms of the acrocentric chromosomes (13 to 15 and 21 - 22)) sometimes highlighted problems with regard to their safety and their pathogenicity. Polymorphisms are usually found in the same family and transmitted in the dominant Mendelian. Chromosome 9 inversion is a frequent phenomenon that some cytogeneticists consider as a variant of normal. Despite its classification as a minor chromosome rearrangement which does not correspond to abnormal phenotypes, many reports have raised conflicting opinions as well, and its complete safety is controversial. 27 cases of inversion of chromosome 9 were identified in our laboratory. The main indications for karyotype of the case of inv (9) were congenital cardiopathy (18.5%), sex development disorders of (18.5%), down syndrome (18.5%), and infertility (14.8%). This study stood out the observations of many authors who highlighted the involvement of inv (9) in the genesis of several pathologies.
%K Inversion
%K Chromosome 9
%K Karyotype
%K Abnormality
%K Fertility
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=111128