%0 Journal Article
%T Impact of Preoperative Serum Tumor Markers in Patients with Lung Squamous Cell Carcinoma
%A Masaki Tomita
%A Shoei Kuroki
%A Tomoka Hamahiro
%A Ryo Maeda
%A Takanori Ayabe
%J Advances in Lung Cancer
%P 48-55
%@ 2169-2726
%D 2021
%I Scientific Research Publishing
%R 10.4236/alc.2021.103005
%X <b>Background:</b> Several previous researchers have investigated the prognostic value of serum tumor markers, especially carcinoembryonic antigen (CEA). Only a limited number of studies reported the usefulness of serum tumor markers for lung squamous cell carcinoma (SQ). We aimed to examine the significance of serum tumor markers for lung SQ. <b>Methods:</b> Eighty-five lung SQ patients who underwent surgery and followed more than 5-year were included. The ratios of 5-year survivors to all patients in groups with several clinicopathologic factors, including tumor markers, were compared. We also compared the clinicopathologic factors between central type and peripheral type SQ. <b>Results:</b> The majority of patients were male gender and current/ former smokers. Age, pN status, cytokeratin-19 fragment (CYFRA 21-1), squamous cell carcinoma antigen (SCC), and comorbid interstitial pneumonia (IP) were associated with the ratio of 5-year survivors significantly. When patients were compared based on tumor location, high p-stage and CYFRA 21-1 were related to central type SQ. <b>Conclusion:</b> Both SCC and CYFRA 21-1 appeared to be useful prognostic markers for patients with lung SQ. Furthermore, CYFRA 21-1 was related to central type SQ.
%K Lung Squamous Cell Carcinoma
%K Cytokeratin-19 Fragment
%K Squamous Cell Carcinoma Antigen
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=111796