%0 Journal Article
%T Isodicentric Ychromosome: Case Study
%A Amal Al Wathnani
%A Suha Tashkandi
%A Khelad Al Saidi
%A Kholoud Al Muteiri
%A Wasmaya Al Enezi
%J Open Journal of Genetics
%P 56-62
%@ 2162-4461
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojgen.2021.113006
%X Isodicentric
chromosomes are a frequently appearing abnormality in the human Y chromosome.
Making predictions regarding the phenotypic outcomes of a variety of
duplications/deletions in the dicentric Y chromosome generally depends on the
breakpoint location and also the level of mosaicism (45, X cell lines); in
certain instances, these may not be detected and result in variations running
between male, abnormal female, or ambiguity in individual genitalia. A referral
was received from a urology clinic concerning two patients, one aged 34 and one
aged 35, with a request to investigate reasons for infertility: G-banded
karyotyping and fluorescence in situ hybridization (FISH) revealed the presence
of an isodicentric Y chromosome.
%K Isodicentric Y
%K Mosaicism
%K Fluorescence in Situ Hybridization
%K SRY
%K G-Banded Karyotyping
%K Infertility
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=112302