%0 Journal Article
%T Synthesis and Stability Studies of <sup>225</sup>Actinium Tin Colloid Radiopharmaceutical
%A Davut Cakici
%A Benan Kilbas
%J Advances in Nanoparticles
%P 23-30
%@ 2169-0529
%D 2022
%I Scientific Research Publishing
%R 10.4236/anp.2022.111003
%X Synthesis of novel <sup>225</sup>Ac-Sn particles was described for the
first time. Detailed experimental and stability studies were successfully
exhibited. Treatment of excess amount of SnCl<sub>2</sub> with 0.2 mCi <sup>225</sup>Ac
furnished highly stable <sup>225</sup>Ac tin colloid with 90% of radiochemical
yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of
radiochemical purity (RCP). Stability studies showed that colloidal structure
also retained free daughter radionuclides formed by the <sup>225</sup>Ac decay
chain. <sup>225</sup>Ac tin colloids could be ideal nanocarriers for localized
cell killing due to high linear energy transfer and prevention of free
radioisotope daughters.
%K &lt
%K sup&gt
%K 225&lt
%K /sup&gt
%K Actinium Tin Colloid
%K Radiosynovectomy
%K Stability
%K Targeted  Alpha-Particle Therapy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=115116