%0 Journal Article
%T Identifying Factors that Affect the Probability of Being Cured from MDR-TB Disease, KwaZulu-Natal, South Africa: A Competing Risks Analysis
%A Sizwe Vincent Mbona
%A Henry Mwambi
%A Retius Chifurira
%J Journal of Tuberculosis Research
%P 1-17
%@ 2329-8448
%D 2022
%I Scientific Research Publishing
%R 10.4236/jtr.2022.101001
%X <b><span style=\"font-family:Verdana;\">Setting:</span></b><span style=\"font-family:Verdana;\"> Four
decentralised sites </span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">are </span></span></span><span><span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">located in rural areas and
one centralised hospital in KwaZulu-Natal province, South Africa. <b></b></span><b><b><span style=\"font-family:Verdana;\">Objective:</span></b><span style=\"font-family:Verdana;\"></span></b> <span style=\"font-family:Verdana;\">To analyse</span><span style=\"font-family:Verdana;\"> risk</span> </span><span style=\"font-family:Verdana;\">f</span><span style=\"font-family:Verdana;\">actors associated with multidrug-resistant
tuberculosis (MDR-TB) using c</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">ompeting risks analysis. Understanding
factors associated with MDR-TB and obtaining valid parameter estimates could
help in designing control and intervention strategies to lower TB mortality. </span><b></b></span><b><b><span style=\"font-family:Verdana;\">Method:</span></b><span style=\"font-family:Verdana;\"></span></b><span style=\"font-family:Verdana;\"> A prospective study was performed using a competing risk analysis in patients
receiving treatment for MDR-TB. The study focused on 1542 patients (aged 18
years and older) who were diagnosed of MDR-TB between July 2008 and June 2010.
Time to cure MDR-TB was used as the dependent variable and time to death was
the com</span></span><span style=\"font-family:Verdana;\">peting risk event</span><span style=\"font-family:Verdana;\">. </span><span style=\"font-family:Verdana;\"><b></b></span><b><b><span style=\"font-family:Verdana;\">Results:</span></b><span style=\"font-family:Verdana;\"></span></b></span><span style=\"font-family:Verdana;\"> The Fine-Gray regression model indicated that b</span><span style=\"font-family:Verdana;\">aseline
weight was highly significant with sub-distribution hazard ration (SHR) = 1.02,
95% CI: 1.01 - 1.02. This means that weight gain in a month increased chances
of curing MDR-TB by 2%. Results show that lower chances to cure MDR-TB w</span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">ere</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> among patients between 41 to 50 years compared to
those patients who were between 18 to 30
%K Competing Risks
%K MDR-TB
%K South Africa
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=115127