%0 Journal Article
%T Safety and Efficacy of a Proprietary Undenatured Beta-Glucan on Different Human Populations
%A Bj£¿rn Kristiansen
%A Ronald J. Amen
%J Advances in Biological Chemistry
%P 16-28
%@ 2162-2191
%D 2022
%I Scientific Research Publishing
%R 10.4236/abc.2022.121002
%X After
proving safety in animal and human models, a series of clinical trials were
conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan
on the immune system; and on self-perceived effects on subjects¡¯ quality of
life (QoL) using a Visual Analogue Scale (VAS). In one study, a subject
population that was self-perceived to be fatigued was administered an
undetaured beta-glucan, to determine if this supplementation affected their
quality-of-life as a result of an increased immune system response. 44 subjects
were administered 1 mg/mL bid of the undenatured beta-glucan (Lentinex®) for
four weeks. Prior to the beginning of the administration, and following the four-week administration period, the subjects were asked to fill out a
quality-of-life VAS questionnaire. The changes in the two questionnaires
revealed differences that occurred as a result of the beta-glucan administration. More than 75% of the subjects scored ¡°better¡± (more
than 1 cm on the
VAS) with regard to feeling in a good mood, and feeling rested. More than 60%
increased their energy and reduced their tiredness and exhaustion, and 70% felt
less stressed. In a second study, subjects aged 40 years and older, believed to be in good general
health, seeking
therapy for tiredness/exhaustion/fatigue or similar conditions (neurasthenia) which were
administered 1 mg/mL bid Lentinex