%0 Journal Article
%T The Study of Effect of Commercial Baicalin Combined with Cefoperazone Sulbactam Sodium on <i>Pseudomonas aeruginosa in Vitro </i>
%A Jiming Li
%A Meide Wei
%A Linghong Wang
%A Yanbo Wu
%A Lu Kang
%A Yan Tang
%A Huan Zhao
%A Yubiao Sun
%J Natural Science
%P 117-124
%@ 2150-4105
%D 2022
%I Scientific Research Publishing
%R 10.4236/ns.2022.143011
%X Objective: To investigate the antibacterial effect of baicalin combined with cefoperazone-sulbactam sodium on drug-resistant strains of <i>Pseudomonas aeruginosa</i>. Method: <i>Pseudomonas aeruginosa</i> strains that are sensitive and resistant to cefoperazone-sulbactam sodium were selected to prepare different test bacterial solutions respectively; The test solutions of baicalin and cefoperazone sulbactam sodium were prepared respectively, and different test groups and control groups were set up; The drug sensitivity tests of different concentration gradients of baicalin and cefoperazone sulbactam sodium used alone and in combination were carried out for different sensitive and drug-resistant strains, and the standard strains were used as parallel control. Result: The drug susceptibility test results of the combined use of baicalin and cefoperazone-sulbactam against <i>Pseudomonas aeruginosa</i> drug-resistant strains were compared with the drug susceptibility results of the two used separately, and the difference was statistically significant (P &lt; 0.05); The combined effect of the two was dependent on strain and concentration. Conclusion: The combined use of baicalin and cefoperazone-sulbactam sodium has a certain synergistic bacteriostatic or bactericidal effect on drug-resistant strains of <i>Pseudomonas aeruginosa</i>.
%K Baicalin
%K Cefoperazone-Sulbactam Sodium
%K Combined Use
%K &lt
%K i&gt
%K Pseudomonas aeruginosa&lt
%K /i&gt
%K Drug Resistance
%K Antibacterial
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=115677