%0 Journal Article
%T Study on the Efficacy of Vitamin C Lotion on Skin: Permeable and Anti-Aging
%A Mengping Wang
%A Wangwang Lu
%A Xinye Ge
%A Yuan Lu
%A Xiwen Jia
%A Huiming Li
%A Qiaoyuan Liu
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 67-82
%@ 2161-4512
%D 2022
%I Scientific Research Publishing
%R 10.4236/jcdsa.2022.121006
%X Vitamin C (ascorbic acid) plays an important role in maintaining skin health, and topical vitamin C supplementation can counteract oxidative stress induced by UVA, due to excellent reducibility. To clarify the efficacy of vitamin C on the skin in the carrier of lotion, we studied its permeability, irritation and anti-aging effect <em>in vitro</em> and <em>in vivo</em>, using Franz cell system, cell model and clinical test. The permeability test showed that vitamin C with 10%, 15%, 20% and 25% mass ratio could effectively penetrate skin. The 20% of vitamin C lotion (VCL-20%) had the highest efficiency of transdermal penetration and the diffusion percentage reached 84.707% after 24 h. Besides, the permeation quantity of VCL-20% was 1.43 times that of the control group. Irritation test showed that the cytotoxicity of vitamin C lotion was low. And no allergic reaction happened in the occlusive patch test. Compared with the control group, using vitamin C lotion for 28 days could significantly improve subjects¡¯ skin gloss of 10.53% and improve skin color, enhance facial skin elasticity and tightness of 9.20% and reduce wrinkle area of 12.27% (<em>p</em> &lt; 0.05).
%K Vitamin C Lotion
%K Efficacy
%K Transdermal Penetration
%K Skin Whitening
%K Anti-Aging
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=116155