%0 Journal Article
%T E-Cadherin的表达调控及对细胞增殖的影响<br> Regulation of E-Cadherin Expression and Effects on Cell Proliferation
%A 王冬杨
%A 吴玉青
%A 应方莉
%A 曹诣斌
%J Bioprocess
%P 10-19
%@ 2164-5582
%D 2022
%I Hans Publishing
%R 10.12677/BP.2022.121002
%X <div style=\"text-align:justify;\">
	<span style=\"font-size:14px;\">E-钙粘蛋白(E-cadherin)主要在上皮细胞膜上表达，发挥细胞间粘附作用并抑制入侵，其在细胞增殖的过程中也扮演着重要角色，主要通过Wnt，Hippo信号通路及Rho家族的小GTPases影响上皮细胞的增殖。E-cadherin在细胞膜上的稳定性和准确的功能通过与连环蛋白(catenin, CAT)形成稳定的复合物来实现。E-cadherin功能缺失在癌症细胞中被发现，其表达失调主要发生在表观遗传学水平。E-cadherin表达水平下降与肿瘤的出现、分化、侵入和运动转移等密切相关。本文主要介绍了E-cadherin对细胞增殖的影响，分析了其在肿瘤发生和发展过程中调节细胞增殖、侵袭和细胞内信号传导的一些分子机制。<br />
E-cadherin is mainly expressed on
epithelial cell membranes, plays an intercellular adhesion and inhibits
invasion, which also plays an important role in cell proliferation, mainly
affecting epithelial cell proliferation through Wnt, Hippo signaling pathways
and small GTPases of the Rho family. The stability and accurate function of
E-cadherin at the cell membrane is achieved by forming a stable complex with
catenin (CAT). Loss of E-cadherin function has been found in cancer cells, and
its dysregulation mainly occurs at the epigenetic level. The decreased
expression level of E-cadherin is closely related to the emergence, differentiation,
invasion and movement metastasis of tumors. This paper mainly introduces the
effect of E-cadherin on cell proliferation and analyzes some of the molecular
mechanisms by which it regulates cell proliferation, invasion and intracellular
signaling during tumorigenesis and development.</span><span style=\"font-size:14px;\"></span><span style=\"font-size:14px;\"></span><br />
</div>
%K E-Cadherin，CAT，细胞增殖，转录调控，癌症<br> E-Cadherin
%K CAT
%K Cell Proliferation
%K Transcriptional Regulation
%K Cancer
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=49526