%0 Journal Article
%T Effects of Diabetes Mellitus upon Sperm Quality Insight into Molecular Level
%A Anna Papadopoulou
%A Petros Karkalousos
%A Maria Trapali
%J Journal of Diabetes Mellitus
%P 75-86
%@ 2160-5858
%D 2022
%I Scientific Research Publishing
%R 10.4236/jdm.2022.122008
%X Diabetes Mellitus is a chronic disease that affects
important body organs in a very serious manner. The consequences of this
disease turn out to be a significant problem for the patient, who tries to cope
with the new condition his organism has been placed in. The most common effect
of the disease, hyperglycaemia, leads over time to serious damage to various
body systems, such as nerves and blood vessels. What is not widely known among
the population is that diabetes may have harmful effects on the reproductive
system of the men suffering from diabetes type 1 and 2 and that such a
parameter could lead to or might be the reason for infertility problems for
couples, for example, miscarriage or embryonic failure. AGEs is a number of
products which are believed to play an important role, because their presence
has been detected in increased level in diabetic men. This implies that those
glycation products might play a key role in diabetic complications. Their
receptor, RAGE, member of the immunoglobulin superfamily has been detected in
the reproductive tract of diabetic men. Reactive oxygen species (ROS), a possible
product of AGEs appear in high levels in seminal plasma and are believed to be
the cause of DNA fragmentation. The objective of this review was to gather all
the available material <i>i.e.</i> studies on
diabetes mellitus in one article, to study the research which has already been
conducted and the conclusions that have been drawn, in order to offer, if
possible, new pathways and perspectives to the scientists, who focus on
fertility problems, sometimes intractable.
%K Diabetes
%K Nuclear Fragmentation
%K Sperm Quality
%K ROS
%K Sperm Motility
%K Sertoli Cells
%K RAGE
%K Sperm Structure
%K Gene Expression
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=116619