%0 Journal Article
%T 用于检测生物硫醇的荧光探针的研究进展<br> Research Progress of Fluorescent Probes for Detection of Biological Thiols
%A 闫鎏鑫
%A 张鹏程
%A 吝丽华
%A 高翔
%A 高林
%A 常晓杰
%A 张杰
%A 周西斌
%J Bioprocess
%P 54-62
%@ 2164-5582
%D 2022
%I Hans Publishing
%R 10.12677/BP.2022.122007
%X <div style=\"text-align:justify;\">
	<span style=\"font-size:14px;\">生物硫醇类化合物，包括L-半胱氨酸、L-同型半胱氨酸和谷胱甘肽等，在许多生理过程中起着十分重要的作用，因此高选择性、高准确度地识别和定量这类化合物对疾病的预防和诊疗起着重要的作用。对生物硫醇的分析方法有很多种，其中荧光探针法由于其选择性高、抗干扰能力强、准确度高且能够用于细胞或动物体内原位成像而受到了越来越多学者的重视。本篇综述按照与生物硫醇发生反应的结构位点，分别介绍了近些年来几种不同类型的荧光探针，不仅有利于生物硫醇分析方法的科学普及，还可以有效地促进新式荧光探针的结构设计和开发。<br />
Biothiols, including L-cysteine,
L-homocysteine, and glutathione, play important roles in many physiological
processes. Therefore, the identification and quantification of such compounds
with high selectivity and accuracy plays an important role in the prevention
and diagnosis of diseases. There are many methods for the analysis of
biological thiols, among which the fluorescent probe method has attracted more
and more scholars due to its high selectivity, strong anti-interference
ability, high accuracy and can be used for in situ imaging of cells or animals.
This review summarizes several different types of fluorescent probes for the
analysis of biothiols in recent years according to the structural sites that
react with biothiols. This review is not only conducive to the scientific
popularization of biological thiol analysis methods, but also can effectively
promote the structural design and development of novel fluorescent probes.</span><span style=\"font-size:14px;\"></span> 
</div>
%K 生物硫醇，荧光，荧光探针，半胱氨酸，高半胱甘酸，谷胱甘肽<br> Biothiols
%K Fluorescence
%K Flu-orescent Probes
%K Cysteine
%K Homocysteine
%K Glutathione
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=52180