%0 Journal Article
%T Synthesis, Characterization of Ruthenium Compounds and Studies of Biological Effects in MCF-7 Tumors Cell Lines
%A Andressa Teixeira de Barros Nunes Ribeiro
%A Claudia Cristina Sousa
%A Adenilda Cristina Hon¨®rio Fran£¿a
%A Eduardo Luzia Fran£¿a
%A Fabricio Tarso Moraes
%A Wagner Batista Santos
%J Advances in Biological Chemistry
%P 61-71
%@ 2162-2191
%D 2022
%I Scientific Research Publishing
%R 10.4236/abc.2022.123006
%X This work presents the synthesis and characterization of compounds
derived from the ruthenium transition metal with the nitrogenous ligand
4-aminopy- ridine (4-ampy). The
synthesized compounds were characterized by FTIRmed spectroscopy and TG-DTA thermal analysis. For the
cytotoxic evaluation of ruthenium compounds, a 66.0 ¦ÌM aqueous solution
containing the complex and the study of data observed in the biological
assessment was performed using variance (ANOVA) analysis, followed by Tukey¡¯s
multiple comparisons test. Differences between treatments were considered
significant when the p-value was less than 0.05 (p < 0.05). TG/DSC thermal
analysis for the first complex suggests a
stoichiometry of [Ru(Cl)3(4-ampy)(H2O)2]¡¤1/2H2O,
which, due to the low solubility in an aqueous medium, was modified to
increase its solubility for biological tests. The analysis of the spectra in
the medium infrared region (FTIR) for the complex [Ru(Cl)3(4-ampy)(H2O)2]¡¤1/2H2O,
shows displacements of the bands observed at 1625 - 1566 cm©1 ¦Í(C=C) e (C=N), indicating that coordination to the
%K Ruthenium
%K MCF-7 Cells
%K Cytotoxic Evaluation
%K N-Heterocyclic Ligands
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=118269