%0 Journal Article
%T Convulsive Seizures Revealing Hashimoto¡¯s Encephalopathy
%A Djikoldinguem Marschall Mouandilmadji
%A Coudjou Josue Dieu-Donne Ghislain de Chacus
%A Kawtar Jamil
%A Maureen Vanessa Ngo Biem
%A Pape Amadou Niane
%A Fatou Bintou Thiam
%A Mame Path¨¦ Diakhate
%A Nafy Ndiaye
%A Abdoulaye Leye
%J World Journal of Neuroscience
%P 105-111
%@ 2162-2019
%D 2022
%I Scientific Research Publishing
%R 10.4236/wjns.2022.123011
%X <b><span style=\"font-family:;\" \"=\"\">Introduction:</span></b><span style=\"font-family:;\" \"=\"\"> Hashimoto encephalopathy (HE) is an autoimmune disease with different
neurological and psychiatric characteristics. It is associated with increased
thyroperoxidase autoantibodies. The diagnosis of HE is clinical and involves
the detection of serum thyroperoxidase (TPO) antibodies and the exclusion of
other etiologies. A clinical response to corticosteroid therapy supports the
diagnosis. We report a case of HE revealed by convulsive seizures and cognitive
and behavioral disorders. <b>Observation:</b> She is a 7-year-old child
followed in a neurology unit for convulsive seizures for one year. Clinical
examination performed in the endocrinology unit later found tachycardia without
goiter, behavioral disorders, difficulties to concentrate as well as
psychomotor agita</span><span style=\"font-family:;\" \"=\"\">tion. Biological work up
revealed subclinical hypothyroidism, positive anti-TPO</span><span style=\"font-family:;\" \"=\"\"> antibodies with normal thyroid ultrasound and brain MRI. The cere</span><span style=\"font-family:;\" \"=\"\">brospinal fluid was clear, normotensive and absence of pleocytosis. The
sleep-wake<span> electroencephalogram was well
organized for her age with a paroxysmal discharge in the left parieto-temporal
region. Based on these clinical, biological </span><span>and morphological data, the diagnosis of HE was retained.
Corticosteroid therapy</span><span> with
prednisone at 1 mg/kg/day was initiated for 6 weeks while </span>reducing the
dose progressively. There was a good clinical and biological progress<span> under treatment. <b>Conclusion:</b> Hashimoto¡¯s
encephalopathy is a rare, but probably unrecognized entity. Over the past
decades, knowledge about thyroid, brain, immunity interactions has increased.
This indicates the importance of a multidisciplinary approach of
endocrinologists, neurologists, psychiatrists and pediatricians for early
recognition and treatment.</span></span>
%K Hypothyroidism
%K Encephalopathy
%K Hashimoto¡¯s Thyroiditis
%K Antithyroperoxidase Antibody
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=119029