%0 Journal Article
%T Synthesis and Anticandidosic Activities of Some 3-Imidazo[1,2-a]Pyridinyl-1-Arylpropenone Derivatives
%A Kouassi Francesco Adingra
%A Souleymane Coulibaly
%A Kacou Alain
%A Mahama Ouattara
%A Drissa Sissouma
%J Advances in Biological Chemistry
%P 81-91
%@ 2162-2191
%D 2022
%I Scientific Research Publishing
%R 10.4236/abc.2022.124008
%X <span style=\"font-family:Verdana;\">In this work, we show the synthesis of ten (10) new derivatives of
3-imidazo</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">[1,2-a]pyridinyl-1-arylpropenone (10a - d). These new compounds were
obtained by condensation of Claisen-Schmidt between derivatives of 2-substi</span><span style=\"font-family:Verdana;\">- </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">tuted-1</span><i><span style=\"font-family:Verdana;\">H</span></i><span style=\"font-family:Verdana;\">-imidazo[1,2-a]pyridine-3-carbaldehyde
(3a - b and </span><b><span style=\"font-family:Verdana;\">7</span></b><span style=\"font-family:Verdana;\">) and acetophenone derivatives (9a - e) in the presence of
a base. The synthesized compounds were characterized by spectroscopic analyses </span><sup><span style=\"font-family:Verdana;\">1</span></sup><span style=\"font-family:Verdana;\">H
and </span><sup><span style=\"font-family:Verdana;\">13</span></sup><span style=\"font-family:Verdana;\">C NMR. The antifungal activity of the ten (10) derivatives was
determined on a resistant strain of </span><i><span style=\"font-family:Verdana;\">Candida</span></i> <i><span style=\"font-family:Verdana;\">albicans</span></i><span style=\"font-family:Verdana;\"> by the microdilution method. The results showed
that four (4) of them (10a, 10b, 10c and 10i) were active with minimum
inhibitory concentrations (MICs) below 300 ¦̀mol/L. Of these four compounds, 10i
was more potent than the others with a MIC of 41.98 ¦̀mol/L.</span></span>
%K Imidazo[1
%K 2-a]Pyridine
%K Arylpropenone
%K &lt
%K i&gt
%K Candida albicans&lt
%K /i&gt
%K Antifungal
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=119112