%0 Journal Article
%T Clinical Study on Pathogenic Factors and Screening Strategies of Retinopathy of Prematurity
%A Syed Manzar Abbas Shah Naqvi
%A Shahrukh Mohammed
%A Hua Ye
%A Yongfeng Zhang
%J Yangtze Medicine
%P 95-113
%@ ****-****
%D 2022
%I Scientific Research Publishing
%R 10.4236/ym.2022.64010
%X <strong>Objective:</strong> To investigate the incidence of retinopathy of prematurity (ROP), analyze the risk factors of ROP, and put forward effective screening strategies, to reduce its incidence. <strong>Background:</strong> Retinopathy of prematurity (ROP) is an eye disease that can happen in new born premature (born early) babies or have weigh less than 3 pounds at birth. ROP happens when abnormal blood vessels grow in the retina. There are multiple risk factors, which are causing the ROP. In our study we will analyses the risk factors of ROP. <strong>Methods:</strong> From February 2016 to August 2021, 190 premature infants in the neonatal intensive care unit (NICU) who received inpatient care and ophthalmic screening was selected as study subjects. ROP group (n = 32) and non-ROP group (n = 158) were selected, and the clinical data of the two groups were compared. Including oxygen concentration, mechanical ventilation, broncho pulmonic dysplasia, delivery mode (cesarean section, vaginal delivery), blood transfusion, anemia, gestational diabetes, gestational hypertension, fetal distress, preterm birth weight, gestation age, etc. Women were divided into two groups according to whether they had gestational diabetes mellitus (GDM) or not: gestational diabetic (n = 38) and non-gestational diabetics (n = 152). Age, pregnancy times, birth times, oxygen inhalation, birth weight, and gestational age were compared between the two groups. The <em>X</em><sup>2</sup> test for counting data and the t-test for measuring data are then conducted according to the distribution characteristics of the data, The correlation analysis between ROP and a single risk factor was performed by chi-square test, and the analysis of the correlation between many risk factors and ROP was conducted by Logistic regression analysis. <strong>Results:</strong> 1) The incidence of ROP in the GDM group was higher than that in the non-GDM group (<em>P </em>&lt; 0.05). 2) Gestational age and birth weight in gestational diabetes mellitus were slightly higher than those in non-gestational diabetic group. But there was no difference in gestational age, birth weight, birth times, gestational times, and age between the two groups (<em>P</em> &gt; 0.05). 3) Univariate analysis showed that oxygen use, birth weight, gestational age, bronchopulmonary dysplasia, pregnancy-induced hypertension, and fetal distress in the ROP group and non-ROP group were statistically significant (<em>P</em> &lt; 0.05). There was no difference in gender, mechanical ventilation, maternal age, and delivery mode between
%K Gestational Diabetes Mellitus
%K Retinopathy of Prematurity
%K Gestational Age
%K Birth Weight
%K Oxygen
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=120385