%0 Journal Article
%T Evaluation of Dosages Regimen of Fluconazole in Patients of Candidemia with Gender by PK/PD and Mote Carlo Simulation
%A Jiuli Hu
%A Xiaolei Yu
%A Junhui Hu
%A Xiaoqin Zhu
%J Open Journal of Blood Diseases
%P 79-86
%@ 2164-3199
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojbd.2022.124008
%X Can<span>didemia is one of the four most
common nosocomial blood infection</span></span></span><span><span><span style=\"font-family:&quot;\">s</span></span></span><span><span><span style=\"font-family:&quot;\"> and is the most common hospital-acquired fungemia
in a recent multi-institutional </span></span></span><span><span><span style=\"font-family:&quot;\">study
from the US. The mortality of Candidemia can be up to 50%</span></span></span><span><span><span style=\"font-family:&quot;\">.</span></span></span><span><span><span style=\"font-family:&quot;\"> Fluconazole is a triazole derivative widely used for the treatment of invasive
candidiasis. It was recommended as first-line drugs for the treatment and
prevention of mycoses. In our study, we aimed to optimise the dosage of
fluconazole with gender against <i>Candida spp</i>. based on
pharmacokinetic/pharmacodynamics (PK/PD) analysis. We collected the published
data about pharmacokinetic parameters of fluconazole and the MIC distribution
of <i>Candida spp.</i> on fluconazole. We
decided to evaluate the gender between males and females with the
pharmacokinetics of fluconazole. Using probability of target attainment (PTA)
and cumulative fraction of response (CFR) as indexes</span></span></span><span><span><span style=\"font-family:&quot;\">, </span></span></span><span><span><span style=\"font-family:&quot;\">crystal
ball software 11.1.2.4 was used for Monte Carlo simulation of different dosage
regimens of different males and females. For<i> C. albicans</i><span>,<i> C. tropicalis and C. lusitaniae</i></span>,
when doses of regimen </span></span></span><span><span><span style=\"font-family:&quot;\">are </span></span></span><span><span><span style=\"font-family:&quot;\">100 mg IV, 200 mg IV and MIC was lower than 1 g/ml, PTA was higher than 90%.
For <i>C. tropicalis</i></span></span></span><span><span><span style=\"font-family:&quot;\">, </span></span></span><span><span><span style=\"font-family:&quot;\">each dosing regimen and MIC was less than 2 g/ml.</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\">PTA was
higher than 90%</span></span></span><span><span><span style=\"font-family:&quot;\">. </span></span></span><span><span><span style=\"font-family:&quot;\">As C. glabrata, C. parapsilosis, C. krusei, C. guilliermondii for PTA with
more than 90%, MIC of fluconazole 200 mg were less than 32 g/ml, 64 g/ml and 64
g/ml, respectively. </span></span></span><span><span><span style=\"font-family:&quot;\">For
%K Monte Carlo Simulation (MSC)
%K Fluconazole
%K Candidemia
%K Gender
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=120924