%0 Journal Article
%T Prevalence and Antibiotic Profile of Multidrug Resistance Gram-Negative Pathogens Isolated from Wound Infections at Two Tertiary Hospitals in Limpopo Province, South Africa: A Retrospective Study
%A Kabelo Gabriel Kaapu
%A Nonyameko Tibello Maguga-Phasha
%A Ngwanamohuba Mologadi Seloma
%A Mbongiseni Cypriel Nkambule
%A Molebogeng Ruth Lekalakala-Mokaba
%J Open Journal of Medical Microbiology
%P 141-155
%@ 2165-3380
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojmm.2022.124013
%X <b><span style=\"font-size:10.0pt;font-family:&quot;\">Background:</span></b><span style=\"font-size:10.0pt;font-family:&quot;\"> There is a high
mortality and morbidity associated with multidrug resistance pathogens. The
high rate of MDR isolates is gradually becoming a threat to the coverage of
antibiotics including the clinical outcome of infected patients. <b>Methods:</b> A 5-year laboratory based antibiotic susceptibility data from January 2016 to
December 2020 was reviewed to determine the most prevalent MDR pathogens
isolated from samples taken from patients with wound infections at Pietersburg
and Mankweng Hospitals. <b>Results:</b> A total of 792 pathogens were analyzed.
The most prevalent isolates were <i>Klebsiella</i> <i>pneumoniae</i> (23%), <i>Pseudomonas</i> <i>aeruginosa</i> (21.7%), <i>Escherichia</i> <i>coli</i> (16%), <i>Proteus</i> <i>mirabilis</i> (13.5%), <i>Acinetobacter</i> <i>baumannii</i> (9.1%) and <i>Klebsiella</i> <i>oxytoca</i> (3.8%). The overall
prevalence of MDR isolates in this study was 38.1%. The distribution of MDR
prevalence amongst these isolates w</span><span style=\"font-size:10.0pt;font-family:&quot;\">as</span><span style=\"font-size:10.0pt;font-family:&quot;\"> <i>K.</i> <i>pneumoniae</i> (20.8%), <i>P.</i> <i>aeruginosa</i> (18.8%), <i>P.</i> <i>mirabilis</i> (17.5%), <i>E.</i> <i>coli</i> (15.9%) and <i>A.</i> <i>baumannii</i> (8.3%). Of the 9
antibiotic agents tested, trimethoprim sulfamethoxazole, tigecycline and
cefepime had the highest levels of resistance. The highest level of resistance
was conferred by <i>K.</i> <i>pneumoniae</i> having 63% of isolates identified as MDR. The study could not determine
statistical significance of any determinant of MDR. <b>Conclusion:</b> The
study revealed that there is high rate of MDR pathogens (38.9%) in Limpopo.
Majority of the pathogens were <i>K.</i> <i>pneumoniae</i> from surgical ward, which also conferred high resistance levels. A proportion of
the MDR pathogens w</span><span style=\"font-size:10.0pt;font-family:&quot;\">as</span><span style=\"font-size:10.0pt;font-family:&quot;\"> identified as A. <i>baumannii</i> CRE pathogens and
is noteworthy in implementation aggressive infection prevention and control
strategies.</span><span style=\"font-size:10.0pt;font-family:&quot;\"></span>
%K Prevalence
%K Antibiotic Profile
%K Multidrug Resistance
%K Wound Pathogens
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=122072