%0 Journal Article
%T Oxazolidinones Antibiotics, Chemistry, Applications and Role in COVID-19 Treatment
%A Alaa Saleh Mahdi
%A Baraa G. Alani
%A Ismail Taha Ibrahim
%J Pharmacology & Pharmacy
%P 19-32
%@ 2157-9431
%D 2023
%I Scientific Research Publishing
%R 10.4236/pp.2023.141002
%X Oxazolidinones are groups of synthetic antimicrobial agents, which have a novel chemical structure. Their mechanism of antimicrobial mainly bacteriostatic via inhibition of protein synthesis. Oxazolidinones are used in serious cases of bacterial infections. Their spectrum of action against a lot of microbes, which often infect humans vigorously, like penicillin and cephalosporin-resistant <em>Streptococcus pneumonia</em>, methicillin-resistant <em>Staphylococcus</em> <em>aureus</em> (MRSA) and vancomycin-resistant <em>enterococci</em>. Oxazolidinones chemical structure possesses a ring called oxazolidone, which is characterized by the <em>S</em> configuration of the substituent at C5, the acyl-amino-methyl group connected to C5 and the N-aryl substituent. Some oxazolidinones like linezolid were believed to have a role in COVID-19 treatment. It is also noticed that oxazolidinones have a role in improving clinical status of patients with COVID-19 and in decreasing the risk of mortality caused by co-infections. This review was conducted to discuss the chemistry, mechanism, applications and role of oxazolidinones in the treatment of COVID-19.
%K Oxazolidinones Antibiotics Linezolid Infection COVID-19
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=122652