%0 Journal Article %T Differences in the US Mpox Outbreaks of 2003 and 2022: A Review %A Sandra R. Henley %A Stephanie Woods-Crawford %J Advances in Infectious Diseases %P 1-11 %@ 2164-2656 %D 2023 %I Scientific Research Publishing %R 10.4236/aid.2023.131001 %X Objectives: This research aims to focus on the differences in mpox outbreaks that occurred in 2003 and 2022 in the United States. Methods: We searched the following databases Medline, Google Scholar, Gayle Power Search, PubMed, and Springerlink using the following search terms ˇ°mpox virusˇ±, ˇ°MPXˇ±, ˇ°mpox in the USˇ±, ˇ°US mpox virus 2003ˇ±, ˇ°US mpox virus 2022ˇ±, ˇ°US mpox outbreak 2003ˇ± and US mpox outbreak 2022ˇ±. The only articles selected were those written between 2003 and 2022. Results: Findings showed more Mpox research was conducted during the first US Mpox outbreak in 2003 compared to the US Mpox outbreak in 2022. Findings also indicated that the mpox outbreak of 2003 consisted of more animal-to-human transmissions acquired from sick prairie dogs compared to more human-to-human from an infected international traveler from Nigeria to the US. Conclusion: Major differences in the mpox outbreaks in the US include the number, location of lesions, and transmission type. We recommend further research to increase awareness of the human-to-human transmission of mpox via sexual contact to assist healthcare professionals and public health leaders in providing prevention and wellness in US communities. %K Mpox %K Mpox Virus %K Mpox Outbreak %K US Mpox 2003 %K US Mpox 2022 %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=122648