%0 Journal Article
%T Prevalence of Extended-Spectrum Beta-Lactamase-Producing Strains Isolated at Zinder National Hospital (ZNH) in 2021 and Their Antibiotic Susceptibility Profile
%A Maman Sani Falissou Sa£¿dou
%A Abdoulaye Ousmane
%A Abdoulaye Inoussa
%A Abdoulaye Maman Bachir
%A Hassane Boureima
%A Lo Gora
%A Alhousseini Maiga Daouda
%A Doutchi Mahamadou
%A Bako Saley Mahaman Laouali
%A Sidi Maman Bacha Boukar
%A Mamadou Saidou
%J Open Journal of Medical Microbiology
%P 43-51
%@ 2165-3380
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojmm.2023.131004
%X Purpose: Bacterial resistance to antibiotics has become a global public health
problem. Enterobacteriaceae ESBL is among the most incriminated in this
emergence which reduces the therapeutic possibilities. Thus, the objective of
this study is to determine the prevalence of the extended-spectrum beta- lactamase (ESBL) producing
Enterobacteriaceae at ZNH and their antibiotic susceptibility profile. Materials
and Methods: This is a prospective study carried out over 5 months in all
hospitalized and non-hospitalized patients in whom a culture was taken for the
diagnosis of an infection. The search for ESBL is done by the double disc
diffusion method. Results: In total, 21 out of 45 of our strains are
ESBL-producing, i.e. a frequency of
46.7%. The mean age is 41.62
(¡À22.90) with extremes of 2.6 - 78 years. The distribution of ESBL producing species
showed a predominance of E. coli with
66.7% followed by K. pneumoniae and K. oxytoca each 9.5%. All ESBL strains
were resistant to Amoxicillin, Cefalotin, Pipiracillin, Piperacillin + tazobactam,
Ticarcillin, Ticarcillin + clavulanic acid. Resistance to C3G and Aztreonam was
each 95.5%, to Amoxicillin/clavulanic acid 9.1%. All strains were sensitive to
imipenem. E. coli strains showed
resistance: 85.7% to ciprofloxacin, 50% to Amikacin, 57.1% to Gentamicin. For K. pneumoniae, it is 66.7%
%K Bacterial Resistance
%K ESBL
%K Enterobacteriaceae
%K Zinder
%K Niger
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=123205